Schematic regulatory pathways for insulin- and diDCP-LA-PE-induced
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Download scientific diagram | Schematic regulatory pathways for insulin- and diDCP-LA-PE-induced GLUT4 translocation. Insulin- or diDCP-LA-PE promotes GLUT4 translocation towards the cell surface through a PI3K/PDK1/Akt pathway and by activating PKCζ. PI3K, alternatively, activates the Rac1 GEF Tiam1, to activate Rac1. Activated Rac1, in turn, binds to and activate the Rac1 effector Dbs, a RhoA GEF, t activate RhoA. Activated RhoA activates the RhoA effector ROCK, leading to GLUT4 translocation towards the cell surface. from publication: Rac1 and ROCK are implicated in the cell surface delivery of GLUT4 under the control of the insulin signal mimetic diDCP-LA-PE | The phosphatidylethanolamine derivative 1,2-O-bis-[8-{2-(2-pentyl-cyclopropylmethyl)-cyclopropyl}-octanoyl]-sn-glycero-3-phosphatidylethanolamine (diDCP-LA-PE) promoted GLUT4 translocation to the cell surface in differentiated 3T3-L1-GLUT4myc adipocytes through a pathway | Insulin Signaling, Rocks and Phosphatidylinositol 3-Kinase | ResearchGate, the professional network for scientists.
Schematic regulatory pathways for insulin- and diDCP-LA-PE-induced
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